GalaxyAbVisc

Antibody viscosity prediction based on protein-protein docking calculation

Method for GalaxyAbVisc

GalaxyAntiVisc calculates the viscosity of antibody solutions from an input antibody structure by performing protein-protein docking calcuation by GalaxyTongDock. It measures the docking affinity between antibody molecules and linearly transforms it to the viscosity value.

Inputs for GalaxyAbVisc

  • Job name: Enter job name for your recognition.
  • E-mail address (Optional): GalaxyWEB server will send progress reports of your job (if provided).
  • Antibody structure: Provide a structure of fragment antigen binding region (fab) in the PDB format.
  • Constant region: Choose a constant region type. (IgG1, IgG2, IgG3, IgG4)
  • pH: Provide the pH of the antibody solution. (default = 6.0)

Outputs for GalaxyAbVisc

Calculated viscosity with docking scores between each domain are shown.

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fv-fv score                 777.174
fv-fc1 score                621.371
fv-fc2 score                689.079
Viscosity at 150mg/mL (cP)    6.557
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